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  2. प्रो. उत्पल चन्द्र डे

Prof. Utpal Chandra De

Professor
Contact Numbers : Mob. 9436470925
E-mails : ucd1972[at]tripurauniv.ac.in , ucd1972[at]tripurauniv.ac.in, ucd1972[at]gmail.com
Academic Qualifications : M.Sc., Ph.D.
Present Designation/position : Professor
Topics Taught : Organic Chemistry

Area Of Research Natural Product Chemistry Organic Synthesis Biochemistry:

Dr. U.C. De has joined in the Department of Chemistry, Tripura University on 30th January 2009. He obtained his M.Sc. and Ph. D from Tripura University in 1997 and 2005 respectively. Before joining in Tripura University, he has worked as Asstt. Professor at N.S. Mahavidyalaya under Higher Education Department, Govt. of Tripura from April, 2002 to 29th January, 2009. He has worked with Dr. A. Basak, Scientist, Department of Biochemistry and Chronic Disease, Ottawa Hospital Research Institute, Ottawa, Canada as Post Doctoral Fellow in the year 2012.

Research Projects :

Sl.No. Title of the Project Funding Agency Status of the Project Total Grant
1 “Synthesis and Characterization of Different Chrysin Derivatives Followed by Screening of Anti-Obesogenic Activity, Antidiabetogenic Activity In Vitro: Assessment of In Vivo Activity With the Lead Compounds” DBT, New Delhi, Govt. of India Running 44.57 lacs
2 Dectin 1 and toll like receptors (TLR) at the interface of beta glucan and macrophage interaction: A mechanistic study of immunomodulatory activity of B-glucan using Leishmaniasis as an immunosuppressive disease model ICMR, GOI as Co-PI Completed 15.65 lacs
3 Anticancer and Antidiabetic Principles for some medicinal plants of Tripura DST as Co-PI Completed 11.00 Lacs
4 Overcoming EGFR resistant Oral Squamous Cell Carcinomas with traditional healers of Tripura – A Preclinical Study DBT, New Delhi, Govt. of India. Completed 47.10 Lacs
5 Phytochemical Investigation and Biological Activity study of Some Medicinal Plants of Tripura CSIR, New Delhi, Govt. of India Completed Rs. 8.5 Lacs
6 Isolation and Characterization of Chemical Constituents of Erioglusum edule and Combretum roxburghii UGC, NERO, Govt. of India Completed 0.95 Lacs

List of Publications:

  1. Combating Staphylococcus aureus biofilm formation: the inhibitory potential of tormentic acid and 23-hydroxycorosolic acid. C. Ghosh, M.C. Das, S. Acharjee, S. Bhattacharjee, P. Sandhu, M. Kumari, J. Bhowmik, R. Ghosh, B. Banerjee, U.C. De and Y. Akhter. Archives of Microbiology (2024).
  2. An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: Insights into molecular mechanisms. B Dinda, M Dinda, S Dinda, UC De. European Journal of Medicinal Chemistry (2023).
  3. Synthesis and Antineoplastic Efficacy of Anthraquinone and Saturated Fatty Acid Conjugates. B Mishra, PC Acharya, UC De. ChemistrySelect (2023).
  4. Water–SDS–[BMIm]Br composite system for onepot multicomponent synthesis of pyrano[2,3-c] pyrazole derivatives and their structural assessment by NMR, X-ray, and DFT studies. Sourav Chakraborty, Bhaswati Paul,Utpal Chandra De, Ramalingam Natarajan and Swapan Majumdar. RSC Advances (2023).
  5. Synthesis of silver nanoparticles using aqueous leaf extract of Premna esculenta and in vivo evaluation of its hepatoprotective activity in Swiss albino male mice. Bijoy Krishna Das, Sourav Ghosh, Antony Gomes & Utpal Chandra De. Inorganic and Nano-Metal Chemistry (2023).
  6. Oroxylum indicum Stem Bark Extract Reduces Tumor Progression by Inhibiting the EGFR-PI3K-AKT Pathway in an In Vivo 4NQO-Induced Oral Cancer Model. M, Parvin, A. Rahaman, A. Sarkar, S. Debnath, UC De, DP Mandal, S Bhattacharjee. Journal of the American Nutrition Association (2022).
  7. Vitexin alters Staphylococcus aureus surface hydrophobicity to obstruct biofilm formation. MC Das, S Samaddar, JJ Jawed, C Ghosh, S Acharjee, P Sandhu, A Das, AV Daware, UC De, S Majumdar, SK Gupta. Microbiological Research (2022).
  8. Synthesis of new chrysin derivatives with substantial antibiofilm activity. S. Bhowmik, P. Anand, R. Das, T. Sen, Y. Akhter, M. C. Das, U.C. De. Mol. Divers (2021).
  9. Synthesis of functionalized pyrimidouracils by ruthenium‐catalyzed oxidative insertion of (hetero)aryl methanols into N‐uracil amidines. P Debnath, G Sahu, UC De, Applied Organometallic Chemistry 35 (2), (2021).
  10. The anti-biofilm potential of triterpenoids isolated from Sarcochlamys pulcherrima (Roxb.) Gaud. C. Ghosh, J. Bhowmik, R. Ghosh, M.C. Das, P. Sandhud, M. Kumari, S. Acharjee, A. V. Daware, Y. Akhter, B. Banerjee, U.C. De, S. Bhattacharjee. Microbial Pathogenesis 139 (2020) 103901
  11. Recent Progress of Adenosine Receptor Modulators in the Development of Anticancer Chemotherapeutic Agents, S. Marwein, B. Mishra, U. Ch. De and P. C. Acharya, Curr. Pharm. Des. 25 (2019), 2842-2858.
  12. Concise Pyrimido [4,5-d]pyrimidine Synthesis via Direct Annulation of N-Uracil Amidines with Benzaldehydes Under Transition Metal Free Conditions. P. Debnath, G. Sahu, U.C. De. Chemistry Select (2019), 4, 2327 –2332
  13. Modulation of S. aureus and P. aeruginosa biofilm: an in vitro study with new coumarin derivatives. T. Das, M.C. Das, A. Das, S. Bhowmik, P. Sandhu, Y. Akhter, S. Bhattacharjee, U. Ch. De. W.J. Microb. and Biotech. (2018). 34:170. https://doi.org/10.1007/s11274-018-2545-1
  14. Physicochemical Characterization of Chrysin-Derivative-Loaded Nanostructured Lipid Carriers with Special Reference to Anticancer Activity. G. Karmakar, P. Nahak, P. Chettri, B. Roy, P. Guha, K. Tsuchiya, K. Torigoe, A. Kumar, R.K. Nath, S. Bhowmik, U.C. De, K. Nag, A.K. Panda. J Surfact Deterg, (2018). 21, 421-432, DOI 10.1002/jsde.12033
  15. Vitexin alters Staphylococcus aureus surface hydrophobicity to interfere with biofilm formation. M.C. Das, A. Das, S. Samaddar, A.V. Dawarea, C. Ghosh, S. Acharjee, P. Sandhu, J.J. Jawed, U.C. De, S. Majumdar, S.K Dasgupta, Y. Akhter, S. Bhattacharjee. bioRxiv (Bio Archive), 301473, (2018).
  16. Synthesis of Some New Chrysin Derivatives and Their Biological Assessment as Antibacterial, Antibiofilm and Antifungal agent. S. Bhowmik, T. Das, S. Ghosh, B. K. Sharma, S. Majumdar, U. C. De. Asian J. Chem., (2018), 30(3), 693-702.
  17. Exploration of Phytoconstituents from Mussaenda roxburghii and Studies of Their Antibiofilm Effect. R. Ghosh, M.C. Das, A. Sarkar, A. Das, P. Sandhu, B. Dinda, Y. Akhter, S. Bhattacharjee, U.C. De. Chem. Biodiversity, 2017, 14 (10), doi: 10.1002/cbdv.201700165. Epub (2017) Sep 20.
  18. Antileishmanial and immunomodulatory activities of lupeol,a triterpene compound isolated from Sterculia villosa. A. Das, J. J. Jawed, M.C. Das, P. Sandhu, U. C. De, B. Dinda, Y. Akhter, S. Bhattacharjee, Int. J. of Antimicrob. Agents, (2017), 50, 512–522.
  19. Inhibiting Epidermal Growth Factor Receptor Signalling Potentiates Mesenchymal-Epithelial Transition of Breast Cancer Stem Cells and their Responsiveness to Anticancer Drugs. K. Manupati, N.R Dhoke, T. Debnath, R. Yeeravalli, K. Guguloth, S. Saeidpour, U. C. De, S. Debnath, A. Das. The FEBS Journal, (2017), doi: 10.1111/febs.14084.
  20. Antibiofilm activity of Parkia javanica against Pseudomonas aeruginosa: a study with fruit extract A. Das, M. C. Das, P. Sandhu, N. Das, P. Tribedi, U. C. De, Y. Akhter, Surajit Bhattacharjee. RSC Advances, (2017),7, 5497-5513.
  21. Anion Dependent Imidazolium Protic Ionic Liquid Catalyzed Solvent‐Free General Strategy for Chemoselective Fmoc and Cbz Protection of Amines and Their Chiral Analogues. A Chakraborty, R. Purkait, U. C. De, D.K. Maiti, S. Majumdar, Chemistry Select, (2016)/, 1 (11), 2668-2672.
  22. Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin, M. C. Das, P. Sandhu, P. Gupta, P. Rudrapaul, U. C. De, P. Tribedi, Y. Akhter, S. Bhattacharjee. Scientific Reports, (2016), 6:23347.
  23. Parkia javanica Extract Induces Apoptosis in S-180 Cells via the Intrinsic Pathway of Apoptosis. K. Patra, S. Jana, A. Sarkar, S. Karmakar, J. Jana, M. Gupta, G. Mukherjee, U. C. De, D. P. Mandal, S. Bhattacharjee. Nutrition and Cancer, (2016), 68(4):689-707.
  24. Isolation And Characterization of A New Flavonoid Glucoside from Aerial Parts of Phrynium Placentarium, U. Ch. De, J. Bhowmik, S. Chowdhury, A. Basak, and B. Dinda, Chemistry of Natural Compounds, Vol. 51, No. 3, pp. 444-447, May, (2015).
  25. 3D-QSAR and docking studies of some structurally diverse flavonoids and design of new aldose reductase inhibitors. U. C. De, T. Debnath, D. Sen, S. Debnath. J. Adv. Pharm. Tech. Res. Vol. 6, 13-18 (2015).
  26. New flavonoids from the fruits of Cornus mas, Cornaceae P. Rudrapaul, A. M. Kyriakopoulos, U. C. De, V. Zoumpourlis, B. Dinda. Phytochemistry Letters 11 (2015) 292–295
  27. New flavonol methyl ether from the leaves of Vitex peduncularis and its potential inhibitory activity against Leishmania donovani through activation of iNOS expression. P. Rudrapaul, B. Dinda, I. Sil Sarma, N. Das, U. C. De, S. Bhattacharjee, European Journal of Medicinal Chemistry, 87 (2014) 328-335.
  28. 3D-QSAR, Docking and ADME Study on Flavone Derivatives as Human Breast Cancer Cell Line MCF-7 Inhibitors, T. Debnath, U. C. De and S. Debnath. Int. J. Res. Pharm. Chem., 808-818, 4(4), 2014.
  29. Preliminary screening for in vitro anti-enteritic properties of a traditional herb Dillenia pentagyna Roxb. fruit extracts. U. C. De, S. Debnath, R. Ghosh. Asian Pac J Trop Biomed. 759-768, 4(S2), 2014.
  30. Studies on Structural Insight of 2-Amino-6-Arylsulfonylbenzonitrile Derivatives as anti HIV Agents. U. C. De, S. Debnath and D. Sen, Int. J. of Res. in Pharm. and Chem., 528-539, 4(3), 2014.
  31. New 19α-hydroxyursane-type triterpenes from the leaves of Meyna spinosa (Vangueria spinosa), Rubiaceae. P. Rudrapaul, N. Das, U. C. De, B. Dinda, Phytochemistry Letters, Vol. 9, 7-10, 2014.
  32. Antibacterial, Anti-Alpha Glucosidase And Antioxidant Properties Of Dillenia Pentagyna Roxb. (Dilleniaceae). A.K.Singha, B. Bhattacharjee, R. Ghosh, U. C. De, D. Maiti, Asian. J. of Pharm. And Clinical Re., 6(4), 173-177, 2013.
  33. Antimicrobial, Antioxidant And Anti Α-Glucosidase Activities Of The Leaf Extract From Mussaenda Roxburghii Hook. F. (Rubiaceae). D. Maiti, B. Bhattacharjee1, A. Kumar Singha, R. Ghosh and U. C. De. World Journal of Pharmacy and Pharmaceutical Sciences, 2(5), 3216-28, 2013.
  34. Pharmacore modeling and 3D-QSAR analysis of flavonoids and congeners active against A549 cell line. S. Debnath, U. C. De, D. Sen B. Dinda., Int. J. Res. Pharm Sc. 3(2), 206-214(2012).
  35. New iridoid from aerial parts of Mussaenda roxburghii. U. C. De, R. Ghosh, S. Chowdhury, B. Dinda. Nat. Prod. Comm, 7 (1), 1-2 (2012).
  36. Antimicrobial C-Glycoside from Aerial Parts of Diospyros nigra, B.Dinda, A. Bhattacharya , U. C. De, S. Arima, H.Takayanagi, Y. Harigaya, Chemical & Pharmaceutical Bulletin, 54(5), 679-681 (2006).
  37. Triterpenoids from Bignonia unguis-cati roots, B. Dinda, U. C. De, S.Arima, N.Sato and Y.Harigaya, Journal of Chemistry Sec B, 44, 1735-1739(2005).
  38. Steroid and Nitrophenol esters from Bignonia unguis-cati roots, B. Dinda, U. C. De, B.Achari, S.Arima, N. Sato and Y.Harigaya, Indian Journal of Chemistry Sec B, 42,1514-1518(2003).
  39. Chemical constituents of Argyrea argentea, Millingtonia hortensis and Pyrostegia venusta. B. Dinda, U.C. De, A. Bhattacharya, S. Arima, N. sato, Y. Harigaya. J. Ind. Chem. Soc. 79, 291-293, (2002).
  40. 19-epialstonine from Amphicome emodi roots, B.Dinda and U. C. De, Indian Journal of Chemistry Sec B, 41, 2698-2700 (2002).
  41. Chemical constituents of Diospyros nigra, B. Dinda, S.K.Das, A. Bhattacharya, U.C.De and Y.Harigaya, Journal of Indian Chemicals Society, 79, 553-554(2002).

Seminar / Conference / Workshop Attended

  1. National Seminar on “Recent Trends in Plant Science Research” held on 15th to 16th March, November, 2016. Organized by Dept. of Botany, Tripura University.
  2. National Seminar on “Biodiversity for Sustainable Development” held on 25th to 26th May, November, 2015. Organized by Dept. of Botany, Tripura University
  3. National Seminar on ‘Recent Advances in Natural Products Chemistry for Drug Discovery’ held on: 28th —29th, November, 2015. Organized by N.S. Mahavidyalaya, Gomati Tripura
  4. 7 Day Workshop on Statistical Data Analysis Methods. Organized jointly by ISRU Unit, Indian Statistical Institute (ISI) Kolkata during 18-24 Nov, 2015 at Tripura University.
  5. Refresher course on “Thin films and Nanoscience” 4 - 18 May, 2015, Organized by: Indian Academy of Sciences, Bangalore; Indian National Science Academy, New Delhi; The National Academy of Sciences, Allahabad, Dept. of Physics, Tripura University.
  6. National Seminar on “Recent trends of research in Chemistry-A new Horizon of hopes” Organized by Department of Chemistry, Women’s’ College on 8-9th August, 2015.
  7. National Seminar on “Biodiversity for Sustainable Development” held on May 25-26, 2015. Organized by Dept. of Forestry and Biodiversity & Dept. of Zoology, Tripura University.
  8. National Conference on “Recent Advances in Cancer Biology and Therapeutics-2014 (RACBT-2014)”, on December 5th 2014, Organized by Dept. of Biotechnology, IIT Guwahati, Assam, India.
  9. Workshop on “Materials & Green Chemistry”, 29-30th November, 2013, Organized by Department of Chemistry, National Institute of Technology, Agartala, West Tripura.
  10. International Conference on Material Science-2013, 21-23rd February, 2013. 27-29th December, 2013, Organized by Department of Physics, Tripura University.
  11. UGC sponsored Refresher course in “Modern Chemical Sciences: Theories and Applications” at UGC academic Staff College, Jadavpur University on 02.01.2013 to 22.01.2013.
  12. Workshop on Developing R & D Proposals for States of North Eastern Region, India, 18-19th October, 2012, Tripura State Council for Science and Technology, Govt. of Tripura.
  13. Fifteenth National conference on Surfactants, Emulsions and Biocolloids, 27-29th December, 2011, Organized by Department of Chemistry, Tripura University, Suryamaninagar , Tripura – 799 022.
  14. National Workshop on “Recent Advances in In-Silico Drug Design and X-Ray Crystallography”, 25-30th July, 2011, Organized by Department of Biotechnology and Bioinformatics, NEHU, Shillong.
  15. One Day Seminar on Recent Developments in Computer Aided Drug Design,13th June, 2011, Organized by Department of Chemistry, M.B.B. College, Agartala.
  16. International Conference on “Emerging Areas of Chemistry”, 12-14th January, 2011, Organized by the Department of Chemistry, Tripura University.
  17. State Level Seminar on Frontier Areas of Chemistry, 3rd September, 2010, Organized jointly by Department of Chemistry, Tripura University, Tripura Chemical Society, Agartala and State Council of Science &Technology, Govt. of Tripura.
  18. National Seminar on Scope and Recent Development of Natural Products 12 – 13th November, 2010, Organised by Iswarchandra Vidyasagar College, Belonia, Tripura – 799 302.
  19. Regional Seminar on Recent Trends in Chemistry, Organized by Department of Chemistry, Govt. Degree College, Dharmanagar, Tripura – 799 251, held on 12-13th September, 2010,
  20. UGC sponsored Orientation Programme at Academic Staff College, University of Burdwan on 21.12.2005 to 17.01.2006.
  21. 38th Annual Convention of Chemists (Indian Chemical Society) Organized by Department of Chemistry, J.N.V. University, Jodhpur, Rajasthan held on 26 – 29th December, 2001
  22. Workshop on NMR Spectroscopy, 28 – 30th June, 2000, Organized by Regional Sophisticated Instrumentation Center, NEHU, Shillong – 793 003.

Teaching Topics of Interest

Stereochemistry of Organic compounds, Organic Reaction Mechanisms, Pericyclic Reactions, Spectroscopy, Reagents and Name reactions, Carbohydrates, Medicinal Chemistry, Chemistry of Natural Products, and Polymer Chemistry.

Other Information:

Members of Professional Bodies:

  1. Life Member of Indian Chemical Society
  2. Life Member of Indian Association for the Cultivation of Science (IACS), Kolkata.
  3. Life Member of Tripura Chemical Society and at Present Vice-President

Honours / Awards

Dr. De was awarded University Gold medals for securing 1st Class 1st Position in B.Sc. (Chemistry Hons) and M.Sc. (Chemistry) of the year of 1993 and 1995 respectively. He was awarded CSIR (Govt. of India) JRF and SRF through National Eligibility Test (NET).

  1. Joint CSIR-UGC JRF, 1999
  2. University Gold Medal for 1st Class 1st Position in M.Sc in Chemistry – 1995
  3. University Gold Medal for 1st Class 1st Position in B.Sc. in Chemistry – 1993

Research Scholars

Sl.No. Name of the Scholar Title of the thesis Status
1 Prasenjit Rudrapaul Chemical constituents of Vitex peduncularis and few other medicinal plants of Tripura Awarded
2 Ranjit Ghosh Isolation and Structural Studies on Chemical Constituents of Mussaenda Roxburghii and Some Other Medicinal Plants Awarded
3 Joyanta Bhowmik Chemical and Biological Evaluation of some Indigenous Medicinal Plants Awarded
4 Sukhen Bhowmik Synthesis and Biological Evaluation of some new Derivatives of Chrysin and Quercetin Awarded
5 Bijoy Krishna Das Biosynthesis of phytofabricated metal nanoparticles, their characterization and studies of biological potentiality Registered
6 Smt. Bijoyasree Mishra Rational Design, synthesis and antineoplastic evaluations of Anthraquinone derivatives Registered
7 Sri Samir Debnath Attending course work Admitted
8 Sri Rajesh Debnath Attending course work Admitted

Education

Dr. U.C. De earned his B.Sc (Chemistry Hons.) and M.Sc. (Organic Chemistry Specialization) from Tripura University in the year of 1993 and 1995 respectively and received gold medals for securing 1st Class 1st position both in B.Sc. & M.Sc. He has qualified GATE-96, NET in 1998(LS) and 1999 (CSIR). He obtained his Ph.D. Degree in 2005 from Tripura University and his doctoral thesis was on Phytochemistry (Chemistry of Medicinal Plants).

Dr. U.C. De has joined in the Department of Chemistry, Tripura University on January 2009 as Assistant Professor and was promoted to Associate Professor on April, 2016. Before joining in Tripura University, he worked as Assistant Professor at N.S. Mahavidyalaya under Higher Education Department, Govt. of Tripura from April, 2002 to 29th January, 2009. As Post Doctoral Fellow he has worked with Dr. A. Basak, Scientist, Department of Biochemistry and Chronic Disease, Ottawa Hospital Research Institute, Ottawa, Canada in the year 2012.

Research

His doctoral work was on isolation, characterization using various chemical and spectroscopic techniques viz. UV, IR, NMR (both 1D and 2D) & Mass. He also worked on various biological activity studies of the isolated phytochemicals. Accordingly his research interests are on phytochemical analysis and evaluation of medicinal values of various indigenous medicinal plants. Laterally he is also interested in analyzing the variation of biological activities of various ubiquitous plant based natural products through diversified functional alteration of them. In addition, he is also interested in molecular designing work using commercially available molecular modeling software in view of searching potential bio-molecules based on synthetically modified natural products of plant origin.

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